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Region-specific denoising identifies spatial co-expression patterns and intra-tissue heterogeneity in spatially resolved transcriptomics data

Spatially resolved transcriptomics is a relatively new technique that maps transcriptional information within a tissue. Analysis of these datasets is challenging because gene expression values are highly sparse due to dropout events, and there is a lack of tools to facilitate in silico detection and...

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Detalles Bibliográficos
Autores principales: Wang, Linhua, Maletic-Savatic, Mirjana, Liu, Zhandong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663444/
https://www.ncbi.nlm.nih.gov/pubmed/36376296
http://dx.doi.org/10.1038/s41467-022-34567-0