Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel

Understanding how ion channels gate is important for elucidating their physiological roles and targeting them in pathophysiological states. Here, we used SthK, a cyclic nucleotide-modulated channel from Spirochaeta thermophila, to define a ligand-gating trajectory that includes multiple on-pathway i...

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Detalles Bibliográficos
Autores principales: Gao, Xiaolong, Schmidpeter, Philipp A. M., Berka, Vladimir, Durham, Ryan J., Fan, Chen, Jayaraman, Vasanthi, Nimigean, Crina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663499/
https://www.ncbi.nlm.nih.gov/pubmed/36376326
http://dx.doi.org/10.1038/s41467-022-34673-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663499/
https://www.ncbi.nlm.nih.gov/pubmed/36376326
http://dx.doi.org/10.1038/s41467-022-34673-z

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