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Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel
Understanding how ion channels gate is important for elucidating their physiological roles and targeting them in pathophysiological states. Here, we used SthK, a cyclic nucleotide-modulated channel from Spirochaeta thermophila, to define a ligand-gating trajectory that includes multiple on-pathway i...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663499/ https://www.ncbi.nlm.nih.gov/pubmed/36376326 http://dx.doi.org/10.1038/s41467-022-34673-z |