Replication collisions induced by de-repressed S-phase transcription are connected with malignant transformation of adult stem cells

Transcription replication collisions (TRCs) constitute a major intrinsic source of genome instability but conclusive evidence for a causal role of TRCs in tumor initiation is missing. We discover that lack of the H4K20-dimethyltransferase KMT5B (also known as SUV4-20H1) in muscle stem cells de-repre...

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Detalles Bibliográficos
Autores principales: Zhang, Ting, Künne, Carsten, Ding, Dong, Günther, Stefan, Guo, Xinyue, Zhou, Yonggang, Yuan, Xuejun, Braun, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663592/
https://www.ncbi.nlm.nih.gov/pubmed/36376321
http://dx.doi.org/10.1038/s41467-022-34577-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663592/
https://www.ncbi.nlm.nih.gov/pubmed/36376321
http://dx.doi.org/10.1038/s41467-022-34577-y

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