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SFTPB (rs11130866) and NR3C1 (rs41423247) gene variants as potential clinical biomarkers for personalized treatment strategy selection in patients with severe COVID-19 pneumonia

BACKGROUND: Exploring the pathogenetic mechanisms behind severe lung damage in COVID-19 is crucial. In this study, we decided to focus on two molecular markers that affect surfactant metabolism and lung development: the surfactant protein B (SFTPB) and the glucocorticoid receptor (NR3C1) genes. The...

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Detalles Bibliográficos
Autores principales: Fishchuk, Liliia, Rossokha, Zoia, Pokhylko, Valeriy, Cherniavska, Yuliia, Popova, Olena, Vershyhora, Viktoriia, Kovtun, Serhii, Gorovenko, Nataliia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Respiratory Society. Published by Elsevier B.V. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663752/
https://www.ncbi.nlm.nih.gov/pubmed/36460583
http://dx.doi.org/10.1016/j.resinv.2022.10.008