Design, synthesis and biological evaluation of new 3,4-dihydroquinoxalin-2(1H)-one derivatives as soluble guanylyl cyclase (sGC) activators

Herein, we present the structure-based design, synthesis and biological evaluation of novel mono- and di-carboxylic 3,4-dihydroquinoxalin-2(1H)-one derivatives as potential heme-independent activators of soluble guanylate cyclase (sGC). Docking calculations of several known sGC agonists by utilizing...

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Detalles Bibliográficos
Autores principales: Kintos, Dionysios-Panagiotis, Salagiannis, Konstantinos, Vazoura, Vasiliki, Wittrien, Theresa, Papakyriakou, Athanasios, Nikolaropoulos, Sotiris S., Behrends, Soenke, Topouzis, Stavros, Fousteris, Manolis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663877/
https://www.ncbi.nlm.nih.gov/pubmed/36387474
http://dx.doi.org/10.1016/j.heliyon.2022.e11438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663877/
https://www.ncbi.nlm.nih.gov/pubmed/36387474
http://dx.doi.org/10.1016/j.heliyon.2022.e11438

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