The role of KRAS splice variants in cancer biology

The three mammalian RAS genes (HRAS, NRAS and KRAS) encode four proteins that play central roles in cancer biology. Among them, KRAS is mutated more frequently in human cancer than any other oncogene. The pre-mRNA of KRAS is alternatively spliced to give rise to two products, KRAS4A and KRAS4B, whic...

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Detalles Bibliográficos
Autores principales: Nuevo-Tapioles, Cristina, Philips, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663995/
https://www.ncbi.nlm.nih.gov/pubmed/36393833
http://dx.doi.org/10.3389/fcell.2022.1033348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663995/
https://www.ncbi.nlm.nih.gov/pubmed/36393833
http://dx.doi.org/10.3389/fcell.2022.1033348

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