Strategies for developing long-lasting therapeutic nucleic acid aptamer targeting circulating protein: The present and the future

Aptamers are short, single-stranded DNA or RNA oligonucleotide sequences that can bind specific targets. The molecular weight of aptamers (<20 kDa) is lower than the renal filtration threshold (30∼50 kDa), resulting in very short half-lives in vivo, which limit their druggability. The development...

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Detalles Bibliográficos
Autores principales: Zhang, Yihao, Zhang, Huarui, Chan, Daniel Wing Ho, Ma, Yuan, Lu, Aiping, Yu, Sifan, Zhang, Baoting, Zhang, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664076/
https://www.ncbi.nlm.nih.gov/pubmed/36393853
http://dx.doi.org/10.3389/fcell.2022.1048148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664076/
https://www.ncbi.nlm.nih.gov/pubmed/36393853
http://dx.doi.org/10.3389/fcell.2022.1048148

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