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Strategies for developing long-lasting therapeutic nucleic acid aptamer targeting circulating protein: The present and the future
Aptamers are short, single-stranded DNA or RNA oligonucleotide sequences that can bind specific targets. The molecular weight of aptamers (<20 kDa) is lower than the renal filtration threshold (30∼50 kDa), resulting in very short half-lives in vivo, which limit their druggability. The development...
Autores principales: | Zhang, Yihao, Zhang, Huarui, Chan, Daniel Wing Ho, Ma, Yuan, Lu, Aiping, Yu, Sifan, Zhang, Baoting, Zhang, Ge |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664076/ https://www.ncbi.nlm.nih.gov/pubmed/36393853 http://dx.doi.org/10.3389/fcell.2022.1048148 |
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