Loss of autism-candidate CHD8 perturbs neural crest development and intestinal homeostatic balance

Individuals with mutations in CHD8 present with gastrointestinal complaints, yet the underlying mechanisms are understudied. Here, using a stable constitutive chd8 mutant zebrafish model, we found that the loss of chd8 leads to a reduced number of vagal neural crest cells (NCCs), enteric neural and...

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Detalles Bibliográficos
Autores principales: Hayot, Gaëlle, Massonot, Mathieu, Keime, Céline, Faure, Elodie, Golzio, Christelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664244/
https://www.ncbi.nlm.nih.gov/pubmed/36375841
http://dx.doi.org/10.26508/lsa.202201456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664244/
https://www.ncbi.nlm.nih.gov/pubmed/36375841
http://dx.doi.org/10.26508/lsa.202201456

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