Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice

OBJECTIVE: The hypothalamus regulates feeding and glucose homeostasis through the balanced action of different neuropeptides, which are cleaved and activated by the proprotein convertases PC1/3 and PC2. However, the recent association of polymorphisms in the proprotein convertase FURIN with type 2 d...

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Detalles Bibliográficos
Autores principales: Coppola, Ilaria, Brouwers, Bas, Walker, Leanne, Alar, Ceyhun, Meulemans, Sandra, White, Anne, Ramos-Molina, Bruno, Creemers, John W.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664468/
https://www.ncbi.nlm.nih.gov/pubmed/36374777
http://dx.doi.org/10.1016/j.molmet.2022.101627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664468/
https://www.ncbi.nlm.nih.gov/pubmed/36374777
http://dx.doi.org/10.1016/j.molmet.2022.101627

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