Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetes

OBJECTIVE: Lifelong insulin replacement remains the mainstay of type 1 diabetes treatment. Genetic FoxO1 ablation promotes enteroendocrine cell (EECs) conversion into glucose-responsive β-like cells. Here, we tested whether chemical FoxO1 inhibitors can generate β-like gut cells. METHODS: We used Ng...

Descripción completa

Detalles Bibliográficos
Autores principales: Kitamoto, Takumi, Lee, Yun-Kyoung, Sultana, Nishat, Watanabe, Hitoshi, McKimpson, Wendy M., Du, Wen, Fan, Jason, Diaz, Bryan, Lin, Hua V., Leibel, Rudolph L., Belvedere, Sandro, Accili, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664469/
https://www.ncbi.nlm.nih.gov/pubmed/36341906
http://dx.doi.org/10.1016/j.molmet.2022.101624

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664469/
https://www.ncbi.nlm.nih.gov/pubmed/36341906
http://dx.doi.org/10.1016/j.molmet.2022.101624

Ejemplares similares