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Chemical induction of gut β-like-cells by combined FoxO1/Notch inhibition as a glucose-lowering treatment for diabetes
OBJECTIVE: Lifelong insulin replacement remains the mainstay of type 1 diabetes treatment. Genetic FoxO1 ablation promotes enteroendocrine cell (EECs) conversion into glucose-responsive β-like cells. Here, we tested whether chemical FoxO1 inhibitors can generate β-like gut cells. METHODS: We used Ng...
Autores principales: | Kitamoto, Takumi, Lee, Yun-Kyoung, Sultana, Nishat, Watanabe, Hitoshi, McKimpson, Wendy M., Du, Wen, Fan, Jason, Diaz, Bryan, Lin, Hua V., Leibel, Rudolph L., Belvedere, Sandro, Accili, Domenico |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664469/ https://www.ncbi.nlm.nih.gov/pubmed/36341906 http://dx.doi.org/10.1016/j.molmet.2022.101624 |
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