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Comparison of intact protein and digested peptide techniques for high throughput proteotyping of ApoE

INTRODUCTION: Apolipoprotein E (ApoE) genotyping has been shown to have diagnostic value in the evaluation of cardiovascular diseases and neurodegenerative disorders such as Alzheimer’s disease. Although genetic testing is well established for this application, liquid chromatography-mass spectrometr...

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Detalles Bibliográficos
Autores principales: Maus, Anthony, Figdore, Dan, Milosevic, Dragana, Algeciras-Schimnich, Alicia, Bornhorst, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664673/
https://www.ncbi.nlm.nih.gov/pubmed/36380282
http://dx.doi.org/10.1186/s12014-022-09379-5