Structure-activity exploration of a small-molecule allosteric inhibitor of T790M/L858R double mutant EGFR

EGFR is a protein kinase whose aberrant activity is frequently involved in the development of non-small lung cancer (NSCLC) drug resistant forms. The allosteric inhibition of this enzyme is currently one among the most attractive approaches to design and develop anticancer drugs. In a previous study...

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Detalles Bibliográficos
Autores principales: Foschi, Francesca, Tinivella, Annachiara, Crippa, Valentina, Pinzi, Luca, Mologni, Luca, Passarella, Daniele, Rastelli, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665079/
https://www.ncbi.nlm.nih.gov/pubmed/36373202
http://dx.doi.org/10.1080/14756366.2022.2145284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665079/
https://www.ncbi.nlm.nih.gov/pubmed/36373202
http://dx.doi.org/10.1080/14756366.2022.2145284

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