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Structure-activity exploration of a small-molecule allosteric inhibitor of T790M/L858R double mutant EGFR
EGFR is a protein kinase whose aberrant activity is frequently involved in the development of non-small lung cancer (NSCLC) drug resistant forms. The allosteric inhibition of this enzyme is currently one among the most attractive approaches to design and develop anticancer drugs. In a previous study...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665079/ https://www.ncbi.nlm.nih.gov/pubmed/36373202 http://dx.doi.org/10.1080/14756366.2022.2145284 |