Cargando…

The Heart’s Pacemaker Mimics Brain Cytoarchitecture and Function: Novel Interstitial Cells Expose Complexity of the SAN

BACKGROUND: The sinoatrial node (SAN) of the heart produces rhythmic action potentials, generated via calcium signaling within and among pacemaker cells. Our previous work has described the SAN as composed of a hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 (HCN4)-expressing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bychkov, Rostislav, Juhaszova, Magdalena, Barrera, Miguel Calvo-Rubio, Donald, Lorenzo A.H., Coletta, Christopher, Shumaker, Chad, Moorman, Kayla, Sirenko, Syevda Tagirova, Maltsev, Alexander V., Sollott, Steven J., Lakatta, Edward G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665104/ https://www.ncbi.nlm.nih.gov/pubmed/36182566 http://dx.doi.org/10.1016/j.jacep.2022.07.003

Ejemplares similares

Unique Ca(2+)-Cycling Protein Abundance and Regulation Sustains Local Ca(2+) Releases and Spontaneous Firing of Rabbit Sinoatrial Node Cells
por: Vinogradova, Tatiana M., et al.
Publicado: (2018)

Phosphoprotein Phosphatase 1 but Not 2A Activity Modulates Coupled-Clock Mechanisms to Impact on Intrinsic Automaticity of Sinoatrial Nodal Pacemaker Cells
por: Sirenko, Syevda Tagirova, et al.
Publicado: (2021)

Ca(2+) and Membrane Potential Transitions During Action Potentials Are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor Stimulation
por: Yang, Dongmei, et al.
Publicado: (2021)

Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells
por: Stern, Michael D., et al.
Publicado: (2014)

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells
por: Sirenko, Syevda G., et al.
Publicado: (2017)

Modulation of Pacemaker Potentials by Pyungwi-San in Interstitial Cells of Cajal from Murine Small Intestine: Pyungwi-San and Interstitial Cells of Cajal
por: Kim, Jung Nam, et al.
Publicado: (2013)

From two competing oscillators to one coupled-clock pacemaker cell system
por: Yaniv, Yael, et al.
Publicado: (2015)

Functional Heterogeneity of Cell Populations Increases Robustness of Pacemaker Function in a Numerical Model of the Sinoatrial Node Tissue
por: Maltsev, Alexander V., et al.
Publicado: (2022)

Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age‐associated alterations in heart rate variability in vivo
por: Yaniv, Yael, et al.
Publicado: (2016)

Emergence of heartbeat frailty in advanced age I: perspectives from life-long EKG recordings in adult mice
por: Moen, Jack M., et al.
Publicado: (2022)

The “Funny” Current (I(f)) Inhibition by Ivabradine at Membrane Potentials Encompassing Spontaneous Depolarization in Pacemaker Cells
por: Yaniv, Yael, et al.
Publicado: (2012)

Cortical Folding Patterns and Predicting Cytoarchitecture
por: Fischl, Bruce, et al.
Publicado: (2008)

Intracellular targeting of isoproteins in muscle cytoarchitecture
Publicado: (1988)

Adaptations of cytoarchitecture in human dilated cardiomyopathy
por: Pluess, Marlene, et al.
Publicado: (2014)

Computer algorithms for automated detection and analysis of local Ca(2+) releases in spontaneously beating cardiac pacemaker cells
por: Maltsev, Alexander V., et al.
Publicado: (2017)

Analysis of Mitochondrial 3D-Deformation in Cardiomyocytes during Active Contraction Reveals Passive Structural Anisotropy of Orthogonal Short Axes
por: Yaniv, Yael, et al.
Publicado: (2011)

Geometric and topological characterization of the cytoarchitecture of islets of Langerhans
por: Aggarwal, Manu, et al.
Publicado: (2023)

β-Adrenergic Stimulation Synchronizes a Broad Spectrum of Action Potential Firing Rates of Cardiac Pacemaker Cells toward a Higher Population Average
por: Kim, Mary S., et al.
Publicado: (2021)

Crosstalk between Mitochondrial and Sarcoplasmic Reticulum Ca(2+) Cycling Modulates Cardiac Pacemaker Cell Automaticity
por: Yaniv, Yael, et al.
Publicado: (2012)

Mimics in chest disease: interstitial opacities
por: Oikonomou, Anastasia, et al.
Publicado: (2012)

Hypothyroxinemia, iodine deficiency, and subtle changes in migration and cytoarchitecture.
por: Soldin, Offie P
Publicado: (2004)

The Physical Interaction of Myoblasts with the Microenvironment during Remodeling of the Cytoarchitecture
por: Modulevsky, Daniel J., et al.
Publicado: (2012)

Cardiac cytoarchitecture — why the “hardware” is important for heart function!()
por: Ehler, Elisabeth
Publicado: (2016)

Altered cortical Cytoarchitecture in the Fmr1 knockout mouse
por: Lee, Frankie H. F., et al.
Publicado: (2019)

Cytoarchitectural changes in the olfactory bulb of Parkinson’s disease patients
por: Cave, John W, et al.
Publicado: (2016)

Nucleus accumbens cytoarchitecture predicts weight gain in children
por: Rapuano, Kristina M., et al.
Publicado: (2020)

Postnatal Cytoarchitecture and Neurochemical Hippocampal Dysfunction in Down Syndrome
por: Moreno, David G., et al.
Publicado: (2021)

The Interplay Between Hyperthyroidism and Ovarian Cytoarchitecture in Albino Rats
por: Mahmud, Tayyaba, et al.
Publicado: (2021)

The Cytoarchitecture of the Tectal-Related Pallium of Squirrelfish, Holocentrus sp.
por: Demski, Leo S., et al.
Publicado: (2022)

Interstitial Mycosis Fungoides: An Unusual Mimic of Interstitial Granuloma Annulare Not to Miss
por: Singh, Neha, et al.
Publicado: (2022)

The end effector of circadian heart rate variation: the sinoatrial node pacemaker cell
por: Yaniv, Yael, et al.
Publicado: (2015)

Conductive heating mattress leads to ECG changes that mimic pacemaker spikes
por: Bräuer, A., et al.
Publicado: (2020)

Cytoarchitecture of mouse and human subventricular zone in developing cerebral neocortex
por: Tabata, Hidenori, et al.
Publicado: (2011)

Correction: The Physical Interaction of Myoblasts with the Microenvironment during Remodeling of the Cytoarchitecture
por: Modulevsky, Daniel J., et al.
Publicado: (2013)

Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice
por: Mellström, Britt, et al.
Publicado: (2016)

A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture
por: Llorca, Alfredo, et al.
Publicado: (2019)

Human Brainstem and Cerebellum Atlas: Chemoarchitecture and Cytoarchitecture Paired to MRI
por: Agostinelli, Lindsay J., et al.
Publicado: (2023)

Asymmetric signaling across the hierarchy of cytoarchitecture within the human connectome
por: Parkes, Linden, et al.
Publicado: (2022)

Gender and cytoarchitecture differences: Functional connectivity of the hippocampal sub-regions
por: Alahmadi, Adnan A.S., et al.
Publicado: (2023)

Dual Activation of Phosphodiesterase 3 and 4 Regulates Basal Cardiac Pacemaker Function and Beyond
por: Vinogradova, Tatiana M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_phvl461m3j3ik9o2090c0kfsg0