Identification of a novel CDK9 inhibitor targeting the intramolecular hidden cavity of CDK9 induced by Tat binding

HIV-1 transcription is specifically augmented by a transcriptional activator complex composed of Tat, an HIV-1-encoded activator, and the host transcription elongation factor P-TEFb, which is composed of cyclin-dependent kinase 9 (CDK9) and cyclin T1. Several observations suggest that P-TEFb is an a...

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Detalles Bibliográficos
Autores principales: Asamitsu, Kaori, Hirokawa, Takatsugu, Okamoto, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665388/
https://www.ncbi.nlm.nih.gov/pubmed/36378653
http://dx.doi.org/10.1371/journal.pone.0277024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9665388/
https://www.ncbi.nlm.nih.gov/pubmed/36378653
http://dx.doi.org/10.1371/journal.pone.0277024

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