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T cell Repertoire Profiling and the Mechanism by which HLA-B27 Causes Ankylosing Spondylitis
PURPOSE OF REVIEW: Ankylosing spondylitis (AS) is strongly associated with the HLA-B27 gene. The canonical function of HLA-B27 is to present antigenic peptides to CD8 lymphocytes, leading to adaptive immune responses. The ‘arthritogenic peptide’ theory as to the mechanism by which HLA-B27 induces an...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer US
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666335/ https://www.ncbi.nlm.nih.gov/pubmed/36197645 http://dx.doi.org/10.1007/s11926-022-01090-6 |