Interaction preferences between protein side chains and key epigenetic modifications 5-methylcytosine, 5-hydroxymethycytosine and N(6)-methyladenine

Covalent modifications of standard DNA/RNA nucleobases affect epigenetic regulation of gene expression by modulating interactions between nucleic acids and protein readers. We derive here the absolute binding free energies and analyze the binding modalities between key modified nucleobases 5-methylc...

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Detalles Bibliográficos
Autores principales: Hajnic, Matea, Alonso-Gil, Santiago, Polyansky, Anton A., de Ruiter, Anita, Zagrovic, Bojan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666514/
https://www.ncbi.nlm.nih.gov/pubmed/36380112
http://dx.doi.org/10.1038/s41598-022-23585-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666514/
https://www.ncbi.nlm.nih.gov/pubmed/36380112
http://dx.doi.org/10.1038/s41598-022-23585-z

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