High-affinity chromodomains engineered for improved detection of histone methylation and enhanced CRISPR-based gene repression

Histone methylation is an important post-translational modification that plays a crucial role in regulating cellular functions, and its dysregulation is implicated in cancer and developmental defects. Therefore, systematic characterization of histone methylation is necessary to elucidate complex bio...

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Detalles Bibliográficos
Autores principales: Veggiani, G., Villaseñor, R., Martyn, G. D., Tang, J. Q., Krone, M. W., Gu, J., Chen, C., Waters, M. L., Pearce, K. H., Baubec, T., Sidhu, S. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666628/
https://www.ncbi.nlm.nih.gov/pubmed/36379931
http://dx.doi.org/10.1038/s41467-022-34269-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666628/
https://www.ncbi.nlm.nih.gov/pubmed/36379931
http://dx.doi.org/10.1038/s41467-022-34269-7

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