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Binding epitope for recognition of human TRPM4 channel by monoclonal antibody M4M

Mouse monoclonal antibody M4M was recently designed to block human TRPM4 channel. The polypeptide for generating M4M is composed of peptide A1 between the transmembrane segment 5 (S5) and the pore, and a second peptide A2 between the pore and the transmembrane segment 6 (S6). Using peptide microarra...

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Detalles Bibliográficos
Autores principales: Wei, Shunhui, Behn, Julian, Poore, Charlene Priscilla, Low, See Wee, Nilius, Bernd, Fan, Hao, Liao, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666640/
https://www.ncbi.nlm.nih.gov/pubmed/36380063
http://dx.doi.org/10.1038/s41598-022-22077-4