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Reciprocal best structure hits: using AlphaFold models to discover distant homologues

MOTIVATION: The conventional methods to detect homologous protein pairs use the comparison of protein sequences. But the sequences of two homologous proteins may diverge significantly and consequently may be undetectable by standard approaches. The release of the AlphaFold 2.0 software enables the p...

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Detalles Bibliográficos
Autores principales: Monzon, Vivian, Paysan-Lafosse, Typhaine, Wood, Valerie, Bateman, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666668/
https://www.ncbi.nlm.nih.gov/pubmed/36408459
http://dx.doi.org/10.1093/bioadv/vbac072