Non-covalent cyclic peptides simultaneously targeting Mpro and NRP1 are highly effective against Omicron BA.2.75

Available vaccine-based immunity may at high risk of being evaded due to substantial mutations in the variant Omicron. The main protease (Mpro) of SARS-CoV-2 and human neuropilin-1 (NRP1), two less mutable proteins, have been reported to be crucial for SARS-CoV-2 replication and entry into host cell...

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Detalles Bibliográficos
Autores principales: Yin, Shengnan, Mei, Shuang, Li, Zhiqin, Xu, Zhen, Wu, Yuting, Chen, Xiujuan, Liu, Dongmei, Niu, Miao-Miao, Li, Jindong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666779/
https://www.ncbi.nlm.nih.gov/pubmed/36408220
http://dx.doi.org/10.3389/fphar.2022.1037993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666779/
https://www.ncbi.nlm.nih.gov/pubmed/36408220
http://dx.doi.org/10.3389/fphar.2022.1037993

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