Cargando…

Forsythiaside B ameliorates coagulopathies in a rat model of sepsis through inhibition of the formation of PAD4-dependent neutrophil extracellular traps

Forsythiaside B (FTB) is one of the main components of Forsythia suspensa (Thunb.) Vahl and exerts anti-inflammatory and anti-oxidative effects. However, its mechanism of action as a treatment for sepsis remains unclear. In this study, we developed a rat model of sepsis using cecal ligation and punc...

Descripción completa

Detalles Bibliográficos
Autores principales:	He, Wenju, Xi, Qiang, Cui, Huantian, Zhang, Pingping, Huang, Rui, Wang, Taihuan, Wang, Dongqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9666896/ https://www.ncbi.nlm.nih.gov/pubmed/36408247 http://dx.doi.org/10.3389/fphar.2022.1022985

Ejemplares similares

Liang-Ge Decoction Ameliorates Coagulation Dysfunction in Cecal Ligation and Puncture-Induced Sepsis Model Rats through Inhibiting PAD4-Dependent Neutrophil Extracellular Trap Formation
por: He, Wenju, et al.
Publicado: (2023)

Liang-Ge decoction ameliorates acute lung injury in septic model rats through reducing inflammatory response, oxidative stress, apoptosis, and modulating host metabolism
por: He, Wenju, et al.
Publicado: (2022)

Cellular mechanism of action of forsythiaside for the treatment of diabetic kidney disease
por: Xu, Chunmei, et al.
Publicado: (2023)

Neutrophil extracellular traps contribute to coagulopathy after traumatic brain injury
por: Jin, Jiaqi, et al.
Publicado: (2023)

Xuebijing injection inhibited neutrophil extracellular traps to reverse lung injury in sepsis mice via reducing Gasdermin D
por: Shang, Ting, et al.
Publicado: (2022)

Effects of Neutrophil Extracellular Traps in Patients With Septic Coagulopathy and Their Interaction With Autophagy
por: Mao, Jia-Yu, et al.
Publicado: (2021)

MiR-155 Regulates PAD4-Dependent Formation of Neutrophil Extracellular Traps
por: Hawez, Avin, et al.
Publicado: (2019)

Forsythiasides: A review of the pharmacological effects
por: Yang, Hong-Xuan, et al.
Publicado: (2022)

Silver Nanoparticles Induce Neutrophil Extracellular Traps Via Activation of PAD and Neutrophil Elastase
por: Kang, HanGoo, et al.
Publicado: (2021)

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
por: Li, Pingxin, et al.
Publicado: (2010)

Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis
por: Zhang, Hao, et al.
Publicado: (2023)

Geniposide Ameliorates Liver Fibrosis Through Reducing Oxidative Stress and Inflammatory Respose, Inhibiting Apoptosis and Modulating Overall Metabolism
por: Yang, Lu, et al.
Publicado: (2021)

PAD4-Mediated Neutrophil Extracellular Trap Formation Is Not Required for Immunity against Influenza Infection
por: Hemmers, Saskia, et al.
Publicado: (2011)

Forsythiasides-Rich Extract From Forsythiae Fructus Inhibits Mast Cell Degranulation by Enhancing Mitochondrial Ca(2+) Uptake
por: Qi, Ruijuan, et al.
Publicado: (2021)

Selinexor, a selective inhibitor of nuclear export, inhibits human neutrophil extracellular trap formation in vitro
por: Baron, Szilvia, et al.
Publicado: (2022)

Inhibition of Human Neutrophil Extracellular Trap (NET) Production by Propofol and Lipid Emulsion
por: Meier, Angela, et al.
Publicado: (2019)

Jian-Ti-Kang-Yi decoction alleviates poly(I:C)-induced pneumonia by inhibiting inflammatory response, reducing oxidative stress, and modulating host metabolism
por: Cui, Huantian, et al.
Publicado: (2022)

Self-assembling, pH-responsive nanoflowers for inhibiting PAD4 and neutrophil extracellular trap formation and improving the tumor immune microenvironment
por: Zhu, Di, et al.
Publicado: (2022)

Neutrophil extracellular traps promote macrophage pyroptosis in sepsis
por: Chen, Linsong, et al.
Publicado: (2018)

A Comparative Review of Neutrophil Extracellular Traps in Sepsis
por: Li, Ronald H. L., et al.
Publicado: (2018)

Forsythiaside A ameliorates sepsis-induced acute kidney injury via anti-inflammation and antiapoptotic effects by regulating endoplasmic reticulum stress
por: Chen, Yi, et al.
Publicado: (2023)

Exploration of anti-inflammatory mechanism of forsythiaside A and forsythiaside B in CuSO(4)-induced inflammation in zebrafish by metabolomic and proteomic analyses
por: Gong, Lihong, et al.
Publicado: (2020)

Phagocytosis, Degranulation and Extracellular Traps Release by Neutrophils—The Current Knowledge, Pharmacological Modulation and Future Prospects
por: Gierlikowska, Barbara, et al.
Publicado: (2021)

Kaempferol blocks neutrophil extracellular traps formation and reduces tumour metastasis by inhibiting ROS‐PAD4 pathway
por: Zeng, Jie, et al.
Publicado: (2020)

GPR109A controls neutrophil extracellular traps formation and improve early sepsis by regulating ROS/PAD4/Cit-H3 signal axis
por: Guo, Wenjin, et al.
Publicado: (2023)

Review: The Emerging Role of Neutrophil Extracellular Traps in Sepsis and Sepsis-Associated Thrombosis
por: Chen, Zhaoyuan, et al.
Publicado: (2021)

Neutrophil extracellular traps (NETs) exacerbate severity of infant sepsis
por: Colón, David F., et al.
Publicado: (2019)

PRAK Is Required for the Formation of Neutrophil Extracellular Traps
por: Wang, Yan, et al.
Publicado: (2019)

(+)-Borneol inhibits the generation of reactive oxygen species and neutrophil extracellular traps induced by phorbol-12-myristate-13-acetate
por: Chen, Hanze, et al.
Publicado: (2022)

Effectiveness of early heparin therapy on outcomes in critically ill patients with sepsis-induced coagulopathy
por: Huang, Jia-Jia, et al.
Publicado: (2023)

Platelet-derived extracellular vesicles promote endothelial dysfunction in sepsis by enhancing neutrophil extracellular traps
por: Jiang, Meini, et al.
Publicado: (2023)

Neutrophil Extracellular Traps, Sepsis and COVID-19 – A Tripod Stand
por: Ventura-Santana, Esmeiry, et al.
Publicado: (2022)

Role of extracellular vesicles in the development of sepsis-induced coagulopathy
por: Iba, Toshiaki, et al.
Publicado: (2018)

Lysophosphatidic Acid Receptor 3 Suppress Neutrophil Extracellular Traps Production and Thrombosis During Sepsis
por: Pei, Shengqiang, et al.
Publicado: (2022)

Spontaneous formation of neutrophil extracellular traps is associated with autophagy
por: Guo, Yun, et al.
Publicado: (2021)

c-Abl kinase regulates neutrophil extracellular trap formation and lung injury in abdominal sepsis
por: Hawez, Avin, et al.
Publicado: (2021)

Mechanisms of Neutrophil Extracellular Trap Formation and Regulation in Cancers
por: Zhang, Zhiyuan, et al.
Publicado: (2023)

Lianhua Qingke ameliorates lipopolysaccharide‐induced lung injury by inhibiting neutrophil extracellular traps formation and pyroptosis
por: Peng, Wenjun, et al.
Publicado: (2023)

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps
por: Papayannopoulos, Venizelos, et al.
Publicado: (2010)

Neutrophil Activation and Neutrophil Extracellular Trap Formation in Dialysis Patients
por: Bieber, Scott, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fce31subvelnbgqeobf7d8hi19