Untargeted metabolomics to evaluate polymyxin B toxicodynamics following direct intracerebroventricular administration into the rat brain

There is a dearth of studies focused on understanding pharmacokinetics, pharmacodynamics and toxicodynamics of polymyxins following direct administration to the central nervous system (CNS). In this study, for the first time, untargeted metabolomics were employed to ascertain the perturbations of br...

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Detalles Bibliográficos
Autores principales: Hussein, Maytham, Oberrauch, Sara, Allobawi, Rafah, Cornthwaite-Duncan, Linda, Lu, Jing, Sharma, Rajnikant, Baker, Mark, Li, Jian, Rao, Gauri G., Velkov, Tony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667150/
https://www.ncbi.nlm.nih.gov/pubmed/36420146
http://dx.doi.org/10.1016/j.csbj.2022.10.041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667150/
https://www.ncbi.nlm.nih.gov/pubmed/36420146
http://dx.doi.org/10.1016/j.csbj.2022.10.041

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