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Generation of iPSC-based human-mouse microglial brain chimeras to study senescence of human microglia
Here, we provide a step-by-step protocol for generating human induced pluripotent stem cell (hiPSC)-based microglial mouse brain chimeras. In addition, we detail steps for intracerebral injection of pathological tau and magnetic cell isolation of human microglia from chimeric mouse brains for single...
Autores principales: | Jin, Mengmeng, Ma, Ziyuan, Jiang, Peng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667309/ https://www.ncbi.nlm.nih.gov/pubmed/36595906 http://dx.doi.org/10.1016/j.xpro.2022.101847 |
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