Protocol to identify drug-binding sites in proteins using solution NMR spectroscopy

Dusquetide is a next-generation IDR (innate defense regulator) targeting the major autophagy receptor protein SQSTM1/p62 and modulating the innate immune response. Here, we describe a protocol for determining dusquetide-binding sites of p62 by solution NMR spectroscopy. Step-by-step technique detail...

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Detalles Bibliográficos
Autores principales: Penumutchu, Srinivasa, Liu, Jiuyang, Singh, Upendra K., Kutateladze, Tatiana G., Zhang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667315/
https://www.ncbi.nlm.nih.gov/pubmed/36595882
http://dx.doi.org/10.1016/j.xpro.2022.101842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667315/
https://www.ncbi.nlm.nih.gov/pubmed/36595882
http://dx.doi.org/10.1016/j.xpro.2022.101842

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