Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche

Unlike many solid tumors, epithelial ovarian cancer (EOC) has a clear metastatic predilection to the adipocyte-rich niche, especially the omentum. However, the underlying mechanism driving this process remains incomplete. Here we show that SphK1 is over-expressed in omental metastases compared with...

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Autores principales: Wang, Chen, Ye, Taiyang, Wang, Wenjing, Song, Keqi, Zhu, Jie, Dai, Lan, Di, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667684/
https://www.ncbi.nlm.nih.gov/pubmed/36384540
http://dx.doi.org/10.1186/s40164-022-00358-y
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author Wang, Chen
Ye, Taiyang
Wang, Wenjing
Song, Keqi
Zhu, Jie
Dai, Lan
Di, Wen
author_facet Wang, Chen
Ye, Taiyang
Wang, Wenjing
Song, Keqi
Zhu, Jie
Dai, Lan
Di, Wen
author_sort Wang, Chen
collection PubMed
description Unlike many solid tumors, epithelial ovarian cancer (EOC) has a clear metastatic predilection to the adipocyte-rich niche, especially the omentum. However, the underlying mechanism driving this process remains incomplete. Here we show that SphK1 is over-expressed in omental metastases compared with ovarian primary tumors in EOC patients. In vitro, inhibition of SphK1 suppressed the metastatic ability of EOC induced by adipocytes. In vivo, blockage of SphK1 could attenuate the omental metastasis of EOC. Importantly, SphK1 modulates adipocyte-induced E/N-cadherin switch through Twist1, a key process in EOC metastasis. Our study reveals a previously unrecognized role of SphK1 in modulating the metastatic tropism of EOC to the adipocyte-rich niche, suggesting a new target for EOC therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40164-022-00358-y.
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spelling pubmed-96676842022-11-17 Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche Wang, Chen Ye, Taiyang Wang, Wenjing Song, Keqi Zhu, Jie Dai, Lan Di, Wen Exp Hematol Oncol Correspondence Unlike many solid tumors, epithelial ovarian cancer (EOC) has a clear metastatic predilection to the adipocyte-rich niche, especially the omentum. However, the underlying mechanism driving this process remains incomplete. Here we show that SphK1 is over-expressed in omental metastases compared with ovarian primary tumors in EOC patients. In vitro, inhibition of SphK1 suppressed the metastatic ability of EOC induced by adipocytes. In vivo, blockage of SphK1 could attenuate the omental metastasis of EOC. Importantly, SphK1 modulates adipocyte-induced E/N-cadherin switch through Twist1, a key process in EOC metastasis. Our study reveals a previously unrecognized role of SphK1 in modulating the metastatic tropism of EOC to the adipocyte-rich niche, suggesting a new target for EOC therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40164-022-00358-y. BioMed Central 2022-11-16 /pmc/articles/PMC9667684/ /pubmed/36384540 http://dx.doi.org/10.1186/s40164-022-00358-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Correspondence
Wang, Chen
Ye, Taiyang
Wang, Wenjing
Song, Keqi
Zhu, Jie
Dai, Lan
Di, Wen
Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche
title Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche
title_full Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche
title_fullStr Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche
title_full_unstemmed Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche
title_short Sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche
title_sort sphingosine kinase 1 contributes to the metastatic potential of epithelial ovarian cancer to the adipocyte-rich niche
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667684/
https://www.ncbi.nlm.nih.gov/pubmed/36384540
http://dx.doi.org/10.1186/s40164-022-00358-y
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