WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC

BACKGROUND: Histologically, cytoplasmic deposits of lipids and glycogen are common in clear cell renal cell carcinoma (ccRCC). Owing to the significance of lipid deposition in ccRCC, numerous trials targeting lipid metabolism have shown certain therapeutic potential. The agonism of peroxisome prolif...

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Detalles Bibliográficos
Autores principales: Wang, Rui, Zhao, Jun, Jin, Jiacheng, Tian, Yun, Lan, Lan, Wang, Xuejian, Zhu, Liang, Wang, Jianbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667690/
https://www.ncbi.nlm.nih.gov/pubmed/36384580
http://dx.doi.org/10.1186/s12944-022-01726-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667690/
https://www.ncbi.nlm.nih.gov/pubmed/36384580
http://dx.doi.org/10.1186/s12944-022-01726-7

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