PAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discovery

We describe a novel approach for screening fragments against a protein that combines the sensitivity of DNA-encoded library technology with the ability of fragments to explore what will bind. Each of the members of the library consists of a fragment which is linked to a photoactivatable diazirine mo...

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Detalles Bibliográficos
Autores principales: Ma, Huiyong, Murray, James B., Luo, Huadong, Cheng, Xuemin, Chen, Qiuxia, Song, Chao, Duan, Cong, Tan, Ping, Zhang, Lifang, Liu, Jian, Morgan, Barry A., Li, Jin, Wan, Jinqiao, Baker, Lisa M., Finnie, William, Guetzoyan, Lucie, Harris, Richard, Hendrickson, Nicole, Matassova, Natalia, Simmonite, Heather, Smith, Julia, Hubbard, Roderick E., Liu, Guansai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667776/
https://www.ncbi.nlm.nih.gov/pubmed/36426238
http://dx.doi.org/10.1039/d2md00197g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667776/
https://www.ncbi.nlm.nih.gov/pubmed/36426238
http://dx.doi.org/10.1039/d2md00197g

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