Synthesis, biological evaluation and computational studies of pyrazole derivatives as Mycobacterium tuberculosis CYP121A1 inhibitors

A series of imidazole and triazole diarylpyrazole derivatives were prepared using an efficient 5-step synthetic scheme and evaluated for binding affinity with Mycobacterium tuberculosis (Mtb) CYP121A1 and antimycobacterial activity against Mtb H37Rv. Antimycobacterial susceptibility was measured usi...

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Detalles Bibliográficos
Autores principales: Alshabani, Lama A., Kumar, Amit, Willcocks, Sam J., Srithiran, Gayathri, Bhakta, Sanjib, Estrada, D. Fernando, Simons, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667784/
https://www.ncbi.nlm.nih.gov/pubmed/36426236
http://dx.doi.org/10.1039/d2md00155a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667784/
https://www.ncbi.nlm.nih.gov/pubmed/36426236
http://dx.doi.org/10.1039/d2md00155a

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