Identification of potential inhibitors of brain-specific CYP46A1 from phytoconstituents in Indian traditional medicinal plants

Cytochrome P450 46A1 (CYP46A1) is a crucial enzyme in brain that converts cholesterol to 24 (S) hydroxy cholesterol thereby increasing its polarity to facilitate removal of excess cholesterol from the CNS. The inhibition of CYP46A1 with several synthetic molecules has been investigated extensively f...

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Detalles Bibliográficos
Autores principales: Kaur, Kuldeep, Devi, Bharti, Agrawal, Vishal, Kumar, Rajnish, Sandhir, Rajat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667835/
https://www.ncbi.nlm.nih.gov/pubmed/36404953
http://dx.doi.org/10.1007/s42485-022-00098-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667835/
https://www.ncbi.nlm.nih.gov/pubmed/36404953
http://dx.doi.org/10.1007/s42485-022-00098-x

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