A focus on the discovery of potent and selective cyclic peptide scaffolds for drug development

In the past, cyclic peptide drugs were commonly discovered by isolation of natural products. However, recent efforts predominantly use high-throughput synthetic or genetically encoded libraries to find potent and selective hits against a range of challenging therapeutic targets. Kawamura et al. (Che...

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Detalles Bibliográficos
Autores principales: Saunders, George J., Yudin, Andrei K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667955/
https://www.ncbi.nlm.nih.gov/pubmed/36425493
http://dx.doi.org/10.1039/d2sc90214a
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author Saunders, George J.
Yudin, Andrei K.
author_facet Saunders, George J.
Yudin, Andrei K.
author_sort Saunders, George J.
collection PubMed
description In the past, cyclic peptide drugs were commonly discovered by isolation of natural products. However, recent efforts predominantly use high-throughput synthetic or genetically encoded libraries to find potent and selective hits against a range of challenging therapeutic targets. Kawamura et al. (Chem. Sci., 2022, 13, 3256–3262, https://doi.org/10.1039/D1SC06844J) developed a new workflow that can be applied to mRNA display, using high-throughput clustering, SAR investigations and in silico structural studies. This led to the discovery of nanomolar, serum-stable cyclic peptides against the human glucose-dependent insulinotropic peptide receptor (hGIP-R).
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spelling pubmed-96679552022-11-23 A focus on the discovery of potent and selective cyclic peptide scaffolds for drug development Saunders, George J. Yudin, Andrei K. Chem Sci Chemistry In the past, cyclic peptide drugs were commonly discovered by isolation of natural products. However, recent efforts predominantly use high-throughput synthetic or genetically encoded libraries to find potent and selective hits against a range of challenging therapeutic targets. Kawamura et al. (Chem. Sci., 2022, 13, 3256–3262, https://doi.org/10.1039/D1SC06844J) developed a new workflow that can be applied to mRNA display, using high-throughput clustering, SAR investigations and in silico structural studies. This led to the discovery of nanomolar, serum-stable cyclic peptides against the human glucose-dependent insulinotropic peptide receptor (hGIP-R). The Royal Society of Chemistry 2022-11-04 /pmc/articles/PMC9667955/ /pubmed/36425493 http://dx.doi.org/10.1039/d2sc90214a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Saunders, George J.
Yudin, Andrei K.
A focus on the discovery of potent and selective cyclic peptide scaffolds for drug development
title A focus on the discovery of potent and selective cyclic peptide scaffolds for drug development
title_full A focus on the discovery of potent and selective cyclic peptide scaffolds for drug development
title_fullStr A focus on the discovery of potent and selective cyclic peptide scaffolds for drug development
title_full_unstemmed A focus on the discovery of potent and selective cyclic peptide scaffolds for drug development
title_short A focus on the discovery of potent and selective cyclic peptide scaffolds for drug development
title_sort focus on the discovery of potent and selective cyclic peptide scaffolds for drug development
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9667955/
https://www.ncbi.nlm.nih.gov/pubmed/36425493
http://dx.doi.org/10.1039/d2sc90214a
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