Cargando…

Repositioning of anti-dengue compounds against SARS-CoV-2 as viral polyprotein processing inhibitor

A therapy for COVID-19 (Coronavirus Disease 19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) remains elusive due to the lack of an effective antiviral therapeutic molecule. The SARS-CoV-2 main protease (M(pro)), which plays a vital role in the viral life cycle, is one of th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bajrai, Leena H., Faizo, Arwa A., Alkhaldy, Areej A., Dwivedi, Vivek Dhar, Azhar, Esam I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668197/ https://www.ncbi.nlm.nih.gov/pubmed/36383621 http://dx.doi.org/10.1371/journal.pone.0277328

Ejemplares similares

Pharmacophore-Model-Based Drug Repurposing for the Identification of the Potential Inhibitors Targeting the Allosteric Site in Dengue Virus NS5 RNA-Dependent RNA Polymerase
por: Kumar, Sanjay, et al.
Publicado: (2022)

Mechanistic insights into the Japanese encephalitis virus RNA dependent RNA polymerase protein inhibition by bioflavonoids from Azadirachta indica
por: Dwivedi, Vivek Dhar, et al.
Publicado: (2021)

Glycosylated Flavonoid Compounds as Potent CYP121 Inhibitors of Mycobacterium tuberculosis
por: Bajrai, Leena Hussein, et al.
Publicado: (2022)

Investigating the Mechanism of Action of Anti-Dengue Compounds as Potential Binders of Zika Virus RNA-Dependent RNA Polymerase
por: Alandijany, Thamir A., et al.
Publicado: (2023)

Identification of Antiviral Compounds against Monkeypox Virus Profilin-like Protein A42R from Plantago lanceolata
por: Bajrai, Leena H., et al.
Publicado: (2022)

Cheminformatics Strategies Unlock Marburg Virus VP35 Inhibitors from Natural Compound Library
por: Alsaady, Isra M., et al.
Publicado: (2023)

Discovery of Bispecific Lead Compounds from Azadirachta indica against ZIKA NS2B-NS3 Protease and NS5 RNA Dependent RNA Polymerase Using Molecular Simulations
por: Kumar, Sanjay, et al.
Publicado: (2022)

Virtual screening and molecular dynamics simulation analysis of Forsythoside A as a plant-derived inhibitor of SARS-CoV-2 3CLpro
por: Bibi, Shabana, et al.
Publicado: (2022)

Anti-dengue drug: viral polyprotein, a potential target
por: Mahmood, Syed Uzair, et al.
Publicado: (2016)

Exploration of Microbially Derived Natural Compounds against Monkeypox Virus as Viral Core Cysteine Proteinase Inhibitors
por: Dubey, Amit, et al.
Publicado: (2023)

Discovery of Small Molecules from Echinacea angustifolia Targeting RNA-Dependent RNA Polymerase of Japanese Encephalitis Virus
por: Yadav, Pardeep, et al.
Publicado: (2022)

Coronavirus disease of 2019 (COVID-19) in the Gulf Cooperation Council (GCC) countries: Current status and management practices
por: Alandijany, Thamir A., et al.
Publicado: (2020)

A multi-targeted computational drug discovery approach for repurposing tetracyclines against monkeypox virus
por: Alandijany, Thamir A., et al.
Publicado: (2023)

A global report on the dynamics of COVID-19 with quarantine and hospitalization: A fractional order model with non-local kernel
por: Ahmad, Zubair, et al.
Publicado: (2022)

Pattern of Respiratory Viruses among Pilgrims during 2019 Hajj Season Who Sought Healthcare Due to Severe Respiratory Symptoms
por: Alsayed, Salma M., et al.
Publicado: (2021)

Gene Expression Profiling of Early Acute Febrile Stage of Dengue Infection and Its Comparative Analysis With Streptococcus pneumoniae Infection
por: Bajrai, Leena H., et al.
Publicado: (2021)

Metagenomic Insights into the Microbiome and Resistance Genes of Traditional Fermented Foods in Arabia
por: Yasir, Muhammad, et al.
Publicado: (2023)

Structure-Based Identification of Natural Products as SARS-CoV-2 M(pro) Antagonist from Echinacea angustifolia Using Computational Approaches
por: Bharadwaj, Shiv, et al.
Publicado: (2021)

In vitro screening of anti-viral and virucidal effects against SARS-CoV-2 by Hypericum perforatum and Echinacea
por: Bajrai, Leena Hussein, et al.
Publicado: (2022)

Viral precursor polyproteins: keys of regulation from replication to maturation
por: Yost, Samantha A, et al.
Publicado: (2013)

Computational and In Vitro Experimental Investigations Reveal Anti-Viral Activity of Licorice and Glycyrrhizin against Severe Acute Respiratory Syndrome Coronavirus 2
por: Tolah, Ahmed M., et al.
Publicado: (2021)

Seroprevalence of neutralizing antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers in Makkah, Saudi Arabia
por: Ahmed, Waleed A., et al.
Publicado: (2021)

Polyproteins in structural biology
por: Crépin, Thibaut, et al.
Publicado: (2015)

Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma
por: El-Kafrawy, Sherif A., et al.
Publicado: (2022)

A review on HCV inhibitors: Significance of non-structural polyproteins
por: Ganta, Narayana Murthy, et al.
Publicado: (2019)

A Reliable Indirect ELISA Protocol for Detection of Human Antibodies Directed to SARS-CoV-2 NP Protein
por: Faizo, Arwa A., et al.
Publicado: (2021)

Kaumoebavirus, a New Virus That Clusters with Faustoviruses and Asfarviridae
por: Bajrai, Leena H., et al.
Publicado: (2016)

Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer
por: Bajrai, Leena Hussein, et al.
Publicado: (2021)

Potential Role of Accessory Domains in Polyproteins Encoded by Retrotransposons in Anti-viral Defense of Host Cells
por: Morozov, Sergey Y., et al.
Publicado: (2019)

Amotosalen and ultraviolet A light treatment efficiently inactivates severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in human plasma
por: Azhar, Esam I., et al.
Publicado: (2020)

Nutritional Knowledge and Self-Reported Nutritional Practice against Malnutrition among Physicians in Jeddah, Saudi Arabia
por: Alkhaldy, Areej Ali
Publicado: (2019)

Molecular pathogenesis of Japanese encephalitis and possible therapeutic strategies
por: Kumar, Sanjay, et al.
Publicado: (2022)

Development and Optimization of In-house ELISA for Detection of Human IgG Antibody to SARS-CoV-2 Full Length Spike Protein
por: Alandijany, Thamir A., et al.
Publicado: (2020)

Role of cleavage at the core-E1 junction of hepatitis C virus polyprotein in viral morphogenesis
por: Pène, Véronique, et al.
Publicado: (2017)

Genetic alteration of human MYH6 is mimicked by SARS-CoV-2 polyprotein: mapping viral variants of cardiac interest
por: Anand, Praveen, et al.
Publicado: (2022)

Caveolin-1 in Lipid Rafts Interacts with Dengue Virus NS3 during Polyprotein Processing and Replication in HMEC-1 Cells
por: García Cordero, Julio, et al.
Publicado: (2014)

Outbreak of viral hemorrhagic fever caused by dengue virus type 3 in Al-Mukalla, Yemen
por: Madani, Tariq A, et al.
Publicado: (2013)

Explaining Neighbourhood Variations in the Incidence of Dengue Fever in Jeddah City, Saudi Arabia
por: Alkhaldy, Ibrahim, et al.
Publicado: (2021)

Active viral shedding in a vaccinated hospitalized patient infected with the delta variant (B.1.617.2) of SARS-CoV-2 and challenges of de-isolation
por: Alshukairi, Abeer N., et al.
Publicado: (2022)

Saudi Moumouvirus, the First Group B Mimivirus Isolated from Asia
por: Bajrai, Leena H., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_uefgnn8vh2ddh3ms8nmvf7j0vc