Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes

We performed collapsing analyses on 454,796 UK Biobank (UKB) exomes to detect gene-level associations with diabetes. Recessive carriers of nonsynonymous variants in MAP3K15 were 30% less likely to develop diabetes (P = 5.7 × 10(−10)) and had lower glycosylated hemoglobin (β = −0.14 SD units, P = 1.1...

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Detalles Bibliográficos
Autores principales: Nag, Abhishek, Dhindsa, Ryan S., Mitchell, Jonathan, Vasavda, Chirag, Harper, Andrew R., Vitsios, Dimitrios, Ahnmark, Andrea, Bilican, Bilada, Madeyski-Bengtson, Katja, Zarrouki, Bader, Zoghbi, Anthony W., Wang, Quanli, Smith, Katherine R., Alegre-Díaz, Jesus, Kuri-Morales, Pablo, Berumen, Jaime, Tapia-Conyer, Roberto, Emberson, Jonathan, Torres, Jason M., Collins, Rory, Smith, David M., Challis, Benjamin, Paul, Dirk S., Bohlooly-Y, Mohammad, Snowden, Mike, Baker, David, Fritsche-Danielson, Regina, Pangalos, Menelas N., Petrovski, Slavé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668288/
https://www.ncbi.nlm.nih.gov/pubmed/36383675
http://dx.doi.org/10.1126/sciadv.add5430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668288/
https://www.ncbi.nlm.nih.gov/pubmed/36383675
http://dx.doi.org/10.1126/sciadv.add5430

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