Dysregulation of Synaptic and Developmental Transcriptomic/Proteomic Profiles upon Depletion of MUNC18-1

Absence of presynaptic protein MUNC18-1 (gene: Stxbp1) leads to neuronal cell death at an immature stage before synapse formation. Here, we performed transcriptomic and proteomic profiling of immature Stxbp1 knock-out (KO) cells to discover which cellular processes depend on MUNC18-1. Hippocampi of...

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Detalles Bibliográficos
Autores principales: Van Berkel, Annemiek A., Koopmans, Frank, Gonzalez-Lozano, Miguel Angel, Lammertse, Hanna C. A., Feringa, Femke, Bryois, Julien, Sullivan, Patrick F., Smit, August B., Toonen, Ruud F., Verhage, Matthijs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668351/
https://www.ncbi.nlm.nih.gov/pubmed/36257704
http://dx.doi.org/10.1523/ENEURO.0186-22.2022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668351/
https://www.ncbi.nlm.nih.gov/pubmed/36257704
http://dx.doi.org/10.1523/ENEURO.0186-22.2022

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