Increased slow dynamics defines ligandability of BTB domains

Efficient determination of protein ligandability, or the propensity to bind small-molecules, would greatly facilitate drug development for novel targets. Ligandability is currently assessed using computational methods that typically consider the static structural properties of putative binding sites...

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Detalles Bibliográficos
Autores principales: Kharchenko, Vladlena, Linhares, Brian M., Borregard, Megan, Czaban, Iwona, Grembecka, Jolanta, Jaremko, Mariusz, Cierpicki, Tomasz, Jaremko, Łukasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668832/
https://www.ncbi.nlm.nih.gov/pubmed/36384931
http://dx.doi.org/10.1038/s41467-022-34599-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668832/
https://www.ncbi.nlm.nih.gov/pubmed/36384931
http://dx.doi.org/10.1038/s41467-022-34599-6

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