Toward more potent imidazopyridine inhibitors of Candida albicans Bdf1: Modeling the role of structural waters in selective ligand binding

Novel agents to treat invasive fungal infections are urgently needed because the small number of established targets in pathogenic fungi makes the existing drug repertoire particularly vulnerable to the emergence of resistant strains. Recently, we reported that Candida albicans Bdf1, a bromodomain a...

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Detalles Bibliográficos
Autores principales: Zhou, Yingsheng, Overhulse, Justin M., Dupper, Nathan J., Guo, Yanchun, Kashemirov, Boris A., Wei, Kaiyao, Govin, Jérôme, Petosa, Carlo, McKenna, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669269/
https://www.ncbi.nlm.nih.gov/pubmed/36190786
http://dx.doi.org/10.1002/jcc.26997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669269/
https://www.ncbi.nlm.nih.gov/pubmed/36190786
http://dx.doi.org/10.1002/jcc.26997

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