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Glutamate receptor-interacting protein 1 in D1- and D2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity

BACKGROUND: The nucleus accumbens (NAc) is involved in the expression of cocaine addictive phenotypes, including acquisition, extinction, and reinstatement. In the NAc, D1-medium spiny neurons (MSNs) encode cocaine reward, whereas D2-MSNs encode aversive responses in drug addiction. Glutamate recept...

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Detalles Bibliográficos
Autores principales: Chen, He, Chen, Limei, Yuan, Zhirong, Yuan, Jiajie, Li, Yitong, Xu, Yuesi, Wu, Jieyi, Zhang, Lu, Wang, Guohua, Li, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669444/
https://www.ncbi.nlm.nih.gov/pubmed/36406750
http://dx.doi.org/10.3389/fncel.2022.979078