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Elevated Ca(2+) at the triad junction underlies dysregulation of Ca(2+) signaling in dysferlin-null skeletal muscle

Dysferlin-null A/J myofibers generate abnormal Ca(2+) transients that are slightly reduced in amplitude compared to controls. These are further reduced in amplitude by hypoosmotic shock and often appear as Ca(2+) waves (Lukyanenko et al., J. Physiol., 2017). Ca(2+) waves are typically associated wit...

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Detalles Bibliográficos
Autores principales: Lukyanenko, Valeriy, Muriel, Joaquin, Garman, Daniel, Breydo, Leonid, Bloch, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669649/
https://www.ncbi.nlm.nih.gov/pubmed/36406982
http://dx.doi.org/10.3389/fphys.2022.1032447