AATF/Che‐1 localizes to paraspeckles and suppresses R‐loops accumulation and interferon activation in Multiple Myeloma

Several kinds of stress promote the formation of three‐stranded RNA:DNA hybrids called R‐loops. Insufficient clearance of these structures promotes genomic instability and DNA damage, which ultimately contribute to the establishment of cancer phenotypes. Paraspeckle assemblies participate in R‐loop...

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Detalles Bibliográficos
Autores principales: Bruno, Tiziana, Corleone, Giacomo, Catena, Valeria, Cortile, Clelia, De Nicola, Francesca, Fabretti, Francesca, Gumenyuk, Svitlana, Pisani, Francesco, Mengarelli, Andrea, Passananti, Claudio, Fanciulli, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670196/
https://www.ncbi.nlm.nih.gov/pubmed/35929179
http://dx.doi.org/10.15252/embj.2021109711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670196/
https://www.ncbi.nlm.nih.gov/pubmed/35929179
http://dx.doi.org/10.15252/embj.2021109711

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