Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma

BACKGROUND: Poor infiltration of functioning T cells renders tumors unresponsive to checkpoint-blocking immunotherapies. Here, we identified a combinatorial in situ immunomodulation strategy based on the administration of selected immunogenic drugs and immunotherapy to sensitize poorly T-cell-infilt...

Descripción completa

Detalles Bibliográficos
Autores principales: Lucarini, Valeria, Melaiu, Ombretta, D’Amico, Silvia, Pastorino, Fabio, Tempora, Patrizia, Scarsella, Marco, Pezzullo, Marco, De Ninno, Adele, D’Oria, Valentina, Cilli, Michele, Emionite, Laura, Infante, Paola, Di Marcotullio, Lucia, De Ioris, Maria Antonietta, Barillari, Giovanni, Alaggio, Rita, Businaro, Luca, Ponzoni, Mirco, Locatelli, Franco, Fruci, Doriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670422/
https://www.ncbi.nlm.nih.gov/pubmed/36397148
http://dx.doi.org/10.1186/s13046-022-02525-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670422/
https://www.ncbi.nlm.nih.gov/pubmed/36397148
http://dx.doi.org/10.1186/s13046-022-02525-9

Ejemplares similares