Cargando…

GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells

The role of the alternate G protein–coupled estrogen receptor 1 (GPER1) in colorectal cancer (CRC) development and progression is unclear, not least because of conflicting clinical and experimental evidence for pro- and anti-tumorigenic activities. Here, we show that low concentrations of the estrog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bühler, Miriam, Fahrländer, Jeanine, Sauter, Alexander, Becker, Markus, Wistorf, Elisa, Steinfath, Matthias, Stolz, Ailine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670797/ https://www.ncbi.nlm.nih.gov/pubmed/36384894 http://dx.doi.org/10.26508/lsa.202201499

Ejemplares similares

Estrogens—Origin of Centrosome Defects in Human Cancer?
por: Bühler, Miriam, et al.
Publicado: (2022)

Microtubule plus tips: A dynamic route to chromosomal instability
por: Stolz, Ailine, et al.
Publicado: (2014)

Epstein–Barr virus particles induce centrosome amplification and chromosomal instability
por: Shumilov, Anatoliy, et al.
Publicado: (2017)

Centrosome amplification induced by survivin suppression enhances both chromosome instability and radiosensitivity in glioma cells
por: Saito, T, et al.
Publicado: (2008)

A Mechanism Linking Extra Centrosomes to Chromosomal Instability
por: Ganem, Neil J., et al.
Publicado: (2009)

RABL6A, a Novel RAB-Like Protein, Controls Centrosome Amplification and Chromosome Instability in Primary Fibroblasts
por: Zhang, Xuefeng, et al.
Publicado: (2013)

GPER: An Estrogen Receptor Key in Metastasis and Tumoral Microenvironments
por: Tirado-Garibay, Ana Carolina, et al.
Publicado: (2023)

Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype
por: Lentini, Laura, et al.
Publicado: (2007)

Centrosome Dysfunction Contributes to Chromosome Instability, Chromoanagenesis, and Genome Reprograming in Cancer
por: Pihan, German A.
Publicado: (2013)

Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity
por: Jusino, Shirley, et al.
Publicado: (2018)

Centrosome instability: when good centrosomes go bad
por: Ryniawec, John M., et al.
Publicado: (2021)

Cortical dynein drives centrosome clustering in cells with centrosome amplification
por: Mercadante, Dayna L., et al.
Publicado: (2023)

GPER mediates differential effects of estrogen on colon cancer cell proliferation and migration under normoxic and hypoxic conditions
por: Bustos, Viviana, et al.
Publicado: (2017)

Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER
por: Zekas, Erin, et al.
Publicado: (2015)

Identification of the estrogen receptor GPER in neoplastic and non-neoplastic human testes
por: Rago, Vittoria, et al.
Publicado: (2011)

Targeting the G protein-coupled estrogen receptor (GPER) in obesity and diabetes
por: Sharma, Geetanjali, et al.
Publicado: (2021)

Antizyme Restrains Centrosome Amplification by Regulating the Accumulation of Mps1 at Centrosomes
por: Kasbek, Christopher, et al.
Publicado: (2010)

The G-Protein-Coupled Estrogen Receptor (GPER/GPR30) in Ovarian Granulosa Cell Tumors
por: Heublein, Sabine, et al.
Publicado: (2014)

Centrosomal abnormalities, multipolar mitoses, and chromosomal instability in head and neck tumours with dysfunctional telomeres
por: Gisselsson, D, et al.
Publicado: (2002)

Excessive centrosome abnormalities without ongoing numerical chromosome instability in a Burkitt's lymphoma
por: Duensing, Stefan, et al.
Publicado: (2003)

Cdc6 disruption leads to centrosome abnormalities and chromosome instability in pancreatic cancer cells
por: Youn, Yuna, et al.
Publicado: (2020)

Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma
por: Dementyeva, Elena, et al.
Publicado: (2013)

G-protein Coupled Estrogen Receptor (GPER/GPR30) and Women's Health
por: Kim, Mi-Jin, et al.
Publicado: (2015)

Activation of novel estrogen receptor GPER results in inhibition of cardiocyte apoptosis and cardioprotection
por: LI, WAN-LI, et al.
Publicado: (2015)

Estrogen Activation by Steroid Sulfatase Increases Colorectal Cancer Proliferation via GPER
por: Gilligan, Lorna C., et al.
Publicado: (2017)

Estrogen Signaling in ERα-Negative Breast Cancer: ERβ and GPER
por: Girgert, Rainer, et al.
Publicado: (2019)

Therapeutic Perspectives on the Modulation of G-Protein Coupled Estrogen Receptor, GPER, Function
por: Rouhimoghadam, Milad, et al.
Publicado: (2020)

The effects of GPER on age-associated memory impairment induced by decreased estrogen levels
por: Luo, Wenyu, et al.
Publicado: (2023)

The Role of G Protein-Coupled Estrogen Receptor (GPER) in Vascular Pathology and Physiology
por: Xu, Fujie, et al.
Publicado: (2023)

HTLV-1 Tax: centrosome amplification and cancer
por: Pumfery, Anne, et al.
Publicado: (2006)

Targeting centrosome amplification, an Achilles' heel of cancer
por: Sabat-Pośpiech, Dorota, et al.
Publicado: (2019)

Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects
por: Warfvinge, Karin, et al.
Publicado: (2020)

Does GPER Really Function as a G Protein-Coupled Estrogen Receptor in vivo?
por: Luo, Jing, et al.
Publicado: (2020)

27-Hydroxycholesterol Binds GPER and Induces Progression of Estrogen Receptor-Negative Breast Cancer
por: Avena, Paola, et al.
Publicado: (2022)

The Co-Expression of Estrogen Receptors ERα, ERβ, and GPER in Endometrial Cancer
por: Hojnik, Marko, et al.
Publicado: (2023)

The G Protein-Coupled Estrogen Receptor (GPER): A Critical Therapeutic Target for Cancer
por: Hall, Keith A., et al.
Publicado: (2023)

Therapeutic S and G(2) checkpoint override causes centromere fragmentation in mitosis
por: Stolz, Ailine, et al.
Publicado: (2013)

The G(1 )phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification
por: Harrison, Mary K, et al.
Publicado: (2011)

Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability
por: Kim, Dong Hyun, et al.
Publicado: (2019)

PARP Inhibitor Decreases Akt Phosphorylation and Induces Centrosome Amplification and Chromosomal Aneuploidy in CHO-K1 Cells
por: Tanaka, Masakazu, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_epv3qlk9kahhffuhuh35ucarer