Ribosome-bound Upf1 forms distinct 80S complexes and conducts mRNA surveillance

Upf1, Upf2, and Upf3, the central regulators of nonsense-mediated mRNA decay (NMD), appear to exercise their NMD functions while bound to elongating ribosomes, and evidence for this conclusion is particularly compelling for Upf1. Hence, we used selective profiling of yeast Upf1:ribosome association...

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Detalles Bibliográficos
Autores principales: Ganesan, Robin, Mangkalaphiban, Kotchaphorn, Baker, Richard E., He, Feng, Jacobson, Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670811/
https://www.ncbi.nlm.nih.gov/pubmed/36192133
http://dx.doi.org/10.1261/rna.079416.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670811/
https://www.ncbi.nlm.nih.gov/pubmed/36192133
http://dx.doi.org/10.1261/rna.079416.122

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