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Sequence-based Prediction of the Cellular Toxicity Associated with Amyloid Aggregation within Protein Condensates
[Image: see text] Various neurological dysfunctions are associated with cytotoxic amyloid-containing aggregates formed through the irreversible maturation of protein condensates generated by phase separation. Here, we investigate the amino acid code for this cytotoxicity using TDP-43 deep-sequencing...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670855/ https://www.ncbi.nlm.nih.gov/pubmed/36341999 http://dx.doi.org/10.1021/acs.biochem.2c00499 |