Associations between circulating interferon and kynurenine/tryptophan pathway metabolites: support for a novel potential mechanism for cognitive dysfunction in SLE

OBJECTIVE: Quinolinic acid (QA), a kynurenine (KYN)/tryptophan (TRP) pathway metabolite, is an N-methyl-D-aspartate receptor agonist that can produce excitotoxic neuron damage. Type I and II interferons (IFNs) stimulate the KYN/TRP pathway, producing elevated QA/kynurenic acid (KA), a potential neur...

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Detalles Bibliográficos
Autores principales: Anderson, Erik W, Jin, Ying, Shih, Andrew, Arazi, Arnon, Goodwin, Sara, Roeser, Julien, Furie, Richard A, Aranow, Cynthia, Volpe, Bruce, Diamond, Betty, Mackay, Meggan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Biomarker Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670923/
https://www.ncbi.nlm.nih.gov/pubmed/36384965
http://dx.doi.org/10.1136/lupus-2022-000808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9670923/
https://www.ncbi.nlm.nih.gov/pubmed/36384965
http://dx.doi.org/10.1136/lupus-2022-000808

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