Model Lipid Raft Membranes for Embedding Integral Membrane Proteins: Reconstitution of HMG-CoA Reductase and Its Inhibition by Statins

[Image: see text] For the first time, HMG-CoA reductase, the membrane protein responsible for cholesterol synthesis, was incorporated into a lipid membrane consisting of DOPC:Chol:SM at a 1:1:1 molar ratio, which mimics the lipid rafts of cell membranes. The membrane containing the protein was gener...

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Detalles Bibliográficos
Autores principales: Zaborowska, Michalina, Matyszewska, Dorota, Bilewicz, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671039/
https://www.ncbi.nlm.nih.gov/pubmed/36335466
http://dx.doi.org/10.1021/acs.langmuir.2c02115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671039/
https://www.ncbi.nlm.nih.gov/pubmed/36335466
http://dx.doi.org/10.1021/acs.langmuir.2c02115

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