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GZ17-6.02 kills prostate cancer cells in vitro and in vivo

GZ17-6.02 is undergoing clinical evaluation in solid tumors and lymphoma. We defined the biology of GZ17-6.02 in prostate cancer cells and determined whether it interacted with the PARP1 inhibitor olaparib to enhance tumor cell killing. GZ17-6.02 interacted in a greater than additive fashion with ol...

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Detalles Bibliográficos
Autores principales: Booth, Laurence, Roberts, Jane L., West, Cameron, Dent, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671078/
https://www.ncbi.nlm.nih.gov/pubmed/36408163
http://dx.doi.org/10.3389/fonc.2022.1045459