Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice

Eliciting broadly neutralizing antibodies (bnAbs) is the core of HIV vaccine design. bnAbs specific to the V2-apex region of the HIV envelope acquire breadth and potency with modest somatic hypermutation, making them attractive vaccination targets. To evaluate Apex germline-targeting (ApexGT) vaccin...

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Detalles Bibliográficos
Autores principales: Melzi, Eleonora, Willis, Jordan R., Ma, Krystal M., Lin, Ying-Cing, Kratochvil, Sven, Berndsen, Zachary T., Landais, Elise A., Kalyuzhniy, Oleksandr, Nair, Usha, Warner, John, Steichen, Jon M., Kalyuzhniy, Anton, Le, Amber, Pecetta, Simone, Perez, Manfredo, Kirsch, Kathrin, Weldon, Stephanie R., Falcone, Samantha, Himansu, Sunny, Carfi, Andrea, Sok, Devin, Ward, Andrew B., Schief, William R., Batista, Facundo D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671093/
https://www.ncbi.nlm.nih.gov/pubmed/36179690
http://dx.doi.org/10.1016/j.immuni.2022.09.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671093/
https://www.ncbi.nlm.nih.gov/pubmed/36179690
http://dx.doi.org/10.1016/j.immuni.2022.09.003

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